Anti-SERINC3 antibody (361-410 aa) (STJ95956)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human SERC3 at the amino acid range 361-410
General Information
| Short Description | Rabbit polyclonal anti-Serine incorporator 3 (361-410 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SERINC3 |
| Gene ID | 10955 |
| Uniprot ID | SERC3_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human SERC3 at the amino acid range 361-410 |
| Immunogen Region | 361-410 aa |
| Specificity | TDE1 Polyclonal Antibody detects endogenous levels of TDE1 protein. |
Additional Info
| Post Translational Modifications | N-glycosylated. |
| Function | Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm. Non-ATP-dependent, non-specific lipid transporter for phosphatidylserine, phosphatidylcholine, and phosphatidylethanolamine. Functions as a scramblase that flips lipids in both directions across the membrane. Phospholipid scrambling results in HIV-1 surface exposure of phosphatidylserine and loss of membrane asymmetry, which leads to changes in HIV-1 Env conformation and loss of infectivity. |
| Protein Name | Serine Incorporator 3Tumor Differentially Expressed Protein 1 |
| Database Links | Reactome: R-HSA-977347 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinGolgi Apparatus MembraneCytoplasmPerinuclear Region(Microbial Infection) Upon Hiv-1 InfectionIt Is Redirected To Perinuclear Region Following Interaction With Hiv-1 NefExcluding It From Virions ParticlesThereby Preventing Subsequent Antiviral Defense Activity (Probable) |
| Alternative Antibody Names | Anti-Serine Incorporator 3 antibodyAnti-Tumor Differentially Expressed Protein 1 antibodyAnti-SERINC3 antibodyAnti-DIFF33 antibodyAnti-TDE1 antibodyAnti-SBBI99 antibody |
Information sourced from Uniprot.org