| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:2000 IHC-P:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SEPTIN7 |
| Gene ID: | 989 |
| Uniprot ID: | SEPT7_HUMAN |
| Immunogen Region: | 307-436 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 307-436 of human Septin 7 (NP_001011553.2). |
| Immunogen Sequence: | NYRSRKLAAVTYNGVDNNKN KGQLTKSPLAQMEEERREHV AKMKKMEMEMEQVFEMKVKE KVQKLKDSEAELQRRHEQMK KNLEAQHKELEEKRRQFEDE KANWEAQQRILEQQNSSRTL EKNKKKGKIF |
| Tissue Specificity | Widely expressed. |
| Function | Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation. |
| Protein Name | Septin-7 Cdc10 Protein Homolog |
| Database Links | Reactome: R-HSA-5687128 |
| Cellular Localisation | Cytoplasm Chromosome Centromere Kinetochore Cytoskeleton Spindle Cleavage Furrow Midbody Cilium Axoneme Cell Projection Cilium Flagellum Distributed Throughout The Cytoplasm In Prometaphase Cells Associated With The Spindle During Metaphase Associated With The Central Spindle And At The Cleavage Furrow In Anaphase Cells Detected At The Midbody In Telophase Associated With Actin Stress Fibers Found In The Sperm Annulus |
| Alternative Antibody Names | Anti-Septin-7 antibody Anti-Cdc10 Protein Homolog antibody Anti-SEPTIN7 antibody Anti-CDC10 antibody Anti-SEPT7 antibody |
Information sourced from Uniprot.org