• Immunohistochemistry analysis of paraffin-embedded Rat kidney tissue using SENP2 Rabbit polyclonal antibody (STJ119967) at a dilution of 1:100 (40x lens). High pressure antigen retrieval performed with 0. 01M Citrate Buffer (pH 6. 0) prior to immunohistochemistry staining.
  • Immunohistochemistry analysis of paraffin-embedded Human lung cancer tissue using SENP2 Rabbit polyclonal antibody (STJ119967) at a dilution of 1:100 (40x lens). High pressure antigen retrieval performed with 0. 01M Citrate Buffer (pH 6. 0) prior to immunohistochemistry staining.
  • Immunohistochemistry analysis of paraffin-embedded Mouse kidney tissue using SENP2 Rabbit polyclonal antibody (STJ119967) at a dilution of 1:100 (40x lens). High pressure antigen retrieval performed with 0. 01M Citrate Buffer (pH 6. 0) prior to immunohistochemistry staining.
  • Western blot analysis of various lysates, using SENP2 Rabbit polyclonal antibody (STJ119967) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.

Anti-SENP2 antibody (366-589) (STJ119967)

SKU:
STJ119967

£112.50 - £522.50
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Host: Rabbit
Applications: WB
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-SENP2 (366-589) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SENP2
Gene ID: 59343
Uniprot ID: SENP2_HUMAN
Immunogen Region: 366-589
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 366-589 of human SENP2 (NP_067640.2).
Immunogen Sequence: LELTEDMEKEISNALGHGPQ DEILSSAFKLRITRGDIQTL KNYHWLNDEVINFYMNLLVE RNKKQGYPALHVFSTFFYPK LKSGGYQAVKRWTKGVNLFE QEIILVPIHRKVHWSLVVID LRKKCLKYLDSMGQKGHRIC EILLQYLQDESKTKRNSDLN LLEWTHHSMKPHEIPQQLNG SDCGMFTCKYADYISRDKPI TFTQHQMPLFRKKMVWEILH QQLL
Post Translational Modifications Polyubiquitinated.which leads to proteasomal degradation.
Function Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1. Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB. Acts as a regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS and STING1 during the late phase of viral infection.
Protein Name Sentrin-Specific Protease 2
Axam2
Smt3-Specific Isopeptidase 2
Smt3ip2
Sentrin/Sumo-Specific Protease Senp2
Database Links Reactome: R-HSA-3065679
Cellular Localisation Nucleus
Nuclear Pore Complex
Nucleus Membrane
Peripheral Membrane Protein
Nucleoplasmic Side
Cytoplasm
Shuttles Between Cytoplasm And Nucleus
Alternative Antibody Names Anti-Sentrin-Specific Protease 2 antibody
Anti-Axam2 antibody
Anti-Smt3-Specific Isopeptidase 2 antibody
Anti-Smt3ip2 antibody
Anti-Sentrin/Sumo-Specific Protease Senp2 antibody
Anti-SENP2 antibody
Anti-KIAA1331 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance