• Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using SENP1 Antibody. The picture on the right is blocked with the synthesized peptide.
  • Western blot analysis of lysates from Jurkat cells, using SENP1 Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of various cells using SENP1 Polyclonal Antibody

Anti-SENP1 antibody (1-50 aa) (STJ95601)

SKU:
STJ95601

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Sentrin-specific protease 1 (1-50 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:20000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SENP1
Gene ID: 29843
Uniprot ID: SENP1_HUMAN
Immunogen Region: 1-50 aa
Specificity: SENP1 Polyclonal Antibody detects endogenous levels of SENP1 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human SENP1 at the amino acid range 1-50
Function Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity. Deconjugates SUMO2 from MTA1. Deconjugates SUMO1 from METTL3. Desumoylates CCAR2 which decreases its interaction with SIRT1. Deconjugates SUMO1 from GPS2.
Protein Name Sentrin-Specific Protease 1
Sentrin/Sumo-Specific Protease Senp1
Database Links Reactome: R-HSA-3065679
Reactome: R-HSA-9035034
Cellular Localisation Nucleus
Cytoplasm
Shuttles Between Cytoplasm And Nucleus
Alternative Antibody Names Anti-Sentrin-Specific Protease 1 antibody
Anti-Sentrin/Sumo-Specific Protease Senp1 antibody
Anti-SENP1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance