Anti-SEMG1 antibody (312-462) (STJ11105399)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal Semenogelin-1 (312-462) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SEMG1 |
| Gene ID | 6406 |
| Uniprot ID | SEMG1_HUMAN |
| Immunogen Region | 312-462 |
| Immunogen Sequence | SSIYSQTEEKAQGKSQKQIT IPSQEQEHSQKANKISYQSS STEERRLHYGENGVQKDVSQ RSIYSQTEKLVAGKSQIQAP NPKQEPWHGENAKGESGQST NREQDLLSHEQKGRHQHGSH GGLDIVIIEQEDDSDRHLAQ HLNNDRNPLFT |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 312-462 of human SEMG1 (NP_002998.1). |
Additional Info
| Tissue Specificity | Seminal vesicle. |
| Post Translational Modifications | Transglutaminase substrate. Rapidly cleaved after ejaculation by KLK3/PSA, resulting in liquefaction of the semen coagulum and the progressive release of motile spermatozoa. |
| Function | Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA. Alpha-inhibin-92 and alpha-inhibin-31, derived from the proteolytic degradation of semenogelin, inhibit the secretion of pituitary follicle-stimulating hormone. |
| Protein Name | Semenogelin-1Cancer/Testis Antigen 103Semenogelin ISgi Cleaved Into - Alpha-Inhibin-92 - Alpha-Inhibin-31 - Seminal Basic Protein |
| Database Links | Reactome: R-HSA-6803157Reactome: R-HSA-977225 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Semenogelin-1 antibodyAnti-Cancer/Testis Antigen 103 antibodyAnti-Semenogelin I antibodyAnti-Sgi Cleaved Into - Alpha-Inhibin-92 - Alpha-Inhibin-31 - Seminal Basic Protein antibodyAnti-SEMG1 antibodyAnti-SEMG antibody |
Information sourced from Uniprot.org