Anti-SEMA7A antibody (150-230 aa) (STJ92082)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from CD108 at the amino acid range 150-230
General Information
| Short Description | Rabbit polyclonal anti-Semaphorin-7A (150-230 aa) for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:5000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SEMA7A |
| Gene ID | 8482 |
| Uniprot ID | SEM7A_HUMAN |
| Immunogen | Synthesized peptide derived from CD108 at the amino acid range 150-230 |
| Immunogen Region | 150-230 aa |
| Specificity | CD108 Polyclonal Antibody detects endogenous levels of CD108 protein. |
Additional Info
| Function | Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of pro-inflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes. |
| Protein Name | Semaphorin-7aCdw108Jmh Blood Group AntigenJohn-Milton-Hargen Human Blood Group AgSemaphorin-K1Sema K1Semaphorin-LSema LCd Antigen Cd108 |
| Database Links | Reactome: R-HSA-416700 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorExtracellular SideDetected In A Punctate Pattern On The Cell Membrane Of Basal And Supra-Basal Skin Keratinocytes |
| Alternative Antibody Names | Anti-Semaphorin-7a antibodyAnti-Cdw108 antibodyAnti-Jmh Blood Group Antigen antibodyAnti-John-Milton-Hargen Human Blood Group Ag antibodyAnti-Semaphorin-K1 antibodyAnti-Sema K1 antibodyAnti-Semaphorin-L antibodyAnti-Sema L antibodyAnti-Cd Antigen Cd108 antibodyAnti-SEMA7A antibodyAnti-CD108 antibodyAnti-SEMAL antibody |
Information sourced from Uniprot.org