| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SELENOK (1-94) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SELENOK |
| Gene ID: |
58515 |
| Uniprot ID: |
SELK_HUMAN |
| Immunogen Region: |
1-94 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1-94 of human SELENOK (NP_067060.2). |
| Immunogen Sequence: |
MVYISNGQVLDSRSQSPWRL SLITDFFWGIAEFVVLFFKT LLQQDVKKRRSYGNSSDSRY DDGRGPPGNPPRRMGRINHL RGPSPPPMAGGUGR |
| Tissue Specificity | Highly expressed in heart. |
| Post Translational Modifications | Cleaved by CAPN2/m-calpain in resting macrophages but not in activated macrophages. Macrophage activation up-regulates expression of the calpain inhibitor CAST/calpastatin, resulting in inhibition of CAPN2 activity. Truncated SELENOK proteins produced by failed UGA/Sec decoding are ubiquitinated by the CRL2(KLHDC2) complex, which recognizes the diglycine (Gly-Gly) at the C-terminus of truncated SELENOK proteins. |
| Function | Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration. Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins. Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation. Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function. Plays a role in protection of cells from ER stress-induced apoptosis. Protects cells from oxidative stress when overexpressed in cardiomyocytes. |
| Protein Name | Selenoprotein KSelk |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinCell MembraneProbably Mainly Localized In The Er |
| Alternative Antibody Names | Anti-Selenoprotein K antibodyAnti-Selk antibodyAnti-SELENOK antibodyAnti-SELK antibodyAnti-HSPC030 antibodyAnti-HSPC297 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
