| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SCYL2 |
| Gene ID: | 55681 |
| Uniprot ID: | SCYL2_HUMAN |
| Immunogen Region: | 1-300 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human SCYL2 (NP_060458.3). |
| Immunogen Sequence: | MESMLNKLKSTVTKVTADVT SAVMGNPVTREFDVGRHIAS GGNGLAWKIFNGTKKSTKQE VAVFVFDKKLIDKYQKFEKD QIIDSLKRGVQQLTRLRHPR LLTVQHPLEESRDCLAFCTE PVFASLANVLGNWENLPSPI SPDIKDYKLYDVETKYGLLQ VSEGLSFLHSSVKMVHGNIT PENIILNKSGAWKIMGFDFC VSSTNPSEQEPKFPCKEWDP NLPSLCLPNPEYLAPEYIL |
| Post Translational Modifications | Could autophosphorylate in presence of poly-L-lysine. |
| Function | Component of the AP2-containing clathrin coat that may regulate clathrin-dependent trafficking at plasma membrane, TGN and endosomal system (Probable). A possible serine/threonine-protein kinase toward the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine has not been confirmed. By regulating the expression of excitatory receptors at synapses, plays an essential role in neuronal function and signaling and in brain development. |
| Protein Name | Scy1-Like Protein 2Coated Vesicle-Associated Kinase Of 104 Kda |
| Cellular Localisation | Cytoplasmic VesicleClathrin-Coated VesicleGolgi ApparatusTrans-Golgi Network MembraneEndosome MembraneColocalizes To The Trans-Golgi Network (Tgn) And To Endosomal Membranes With ClathrinTransferrin And Plasma Membrane Adapter Ap1 And Ap3 Complexes |
| Alternative Antibody Names | Anti-Scy1-Like Protein 2 antibodyAnti-Coated Vesicle-Associated Kinase Of 104 Kda antibodyAnti-SCYL2 antibodyAnti-CVAK104 antibodyAnti-KIAA1360 antibody |
Information sourced from Uniprot.org