Anti-SCNN1B antibody (570-640 aa) (STJ13101781)

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STJ13101781-100
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Host: Rabbit
Applications: IHC/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-SCNN1B (570-640 aa) is suitable for use in Immunohistochemistry and Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Lyophilised
Purification: IgG purified
Dilution Range: IHC, WB (using recombinant protein). A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Storage Instruction: Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Gene Symbol: SCNN1B
Gene ID: 6338
Uniprot ID: SCNNB_HUMAN
Immunogen Region: 570-640 aa
Specificity: Specific for SCNN1B.
Immunogen: A synthetic peptide from aa region 570-640 of human SCNN1B conjugated to an immunogenic carrier protein was used as the antigen.
Post Translational Modifications Phosphorylated on serine and threonine residues. Aldosterone and insulin increase the basal level of phosphorylation. N-glycosylated. N-glycosylation is required for interaction with BPIFA1.
Function Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
Protein Name Amiloride-Sensitive Sodium Channel Subunit Beta
Beta-Nach
Epithelial Na(+ Channel Subunit Beta
Beta-Enac
Enacb
Nonvoltage-Gated Sodium Channel 1 Subunit Beta
Scneb
Database Links Reactome: R-HSA-2672351
Reactome: R-HSA-9730628
Cellular Localisation Apical Cell Membrane
Multi-Pass Membrane Protein
Cytoplasmic Vesicle Membrane
Apical Membrane Of Epithelial Cells
Alternative Antibody Names Anti-Amiloride-Sensitive Sodium Channel Subunit Beta antibody
Anti-Beta-Nach antibody
Anti-Epithelial Na(+ Channel Subunit Beta antibody
Anti-Beta-Enac antibody
Anti-Enacb antibody
Anti-Nonvoltage-Gated Sodium Channel 1 Subunit Beta antibody
Anti-Scneb antibody
Anti-SCNN1B antibody

Information sourced from Uniprot.org

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