| Post Translational Modifications | Ubiquitinated. Can be ubiquitinated at multiple sites and undergo monoubiquitination and polyubiquitination. Ubiquitination by NEDD4 or NEDD4L inhibits the ENaC channel through endocytosis, intracellular retention and degradation of its individual subunits. However, some studies could not confirm the ubiquitination of this subunit of the ENaC. Phosphorylated on serine and threonine residues. Aldosterone and insulin increase the basal level of phosphorylation. N-glycosylated. N-glycosylation is required for interaction with BPIFA1. |
| Function | This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis. ENaC operates in epithelial tissues, where it mediates the electrodiffusion of sodium ions from extracellular fluid through the apical membrane of cells, with water following osmotically. It plays a key role in maintaining sodium homeostasis through electrogenic sodium reabsorption in the kidneys. Additionally, ENaC is essential for airway surface liquid homeostasis, which is crucial for proper mucus clearance. |
| Protein Name | Epithelial Sodium Channel Subunit BetaBeta-EnacEnac Subunit BetaEnacbEpithelial Na(+ Channel Subunit BetaAmiloride-Sensitive Sodium Channel Subunit BetaBeta-NachNonvoltage-Gated Sodium Channel 1 Subunit BetaScneb |
| Database Links | Reactome: R-HSA-2672351Reactome: R-HSA-9730628 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinCytoplasmic Vesicle Membrane |
| Alternative Antibody Names | Anti-Epithelial Sodium Channel Subunit Beta antibodyAnti-Beta-Enac antibodyAnti-Enac Subunit Beta antibodyAnti-Enacb antibodyAnti-Epithelial Na(+ Channel Subunit Beta antibodyAnti-Amiloride-Sensitive Sodium Channel Subunit Beta antibodyAnti-Beta-Nach antibodyAnti-Nonvoltage-Gated Sodium Channel 1 Subunit Beta antibodyAnti-Scneb antibodyAnti-SCNN1B antibody |
Information sourced from Uniprot.org
