| Post Translational Modifications | Ubiquitinated. Can be ubiquitinated at multiple sites and undergo monoubiquitination and polyubiquitination. Ubiquitination by NEDD4 or NEDD4L inhibits the ENaC channel through endocytosis, intracellular retention and degradation of its individual subunits. ENaC is activated through the proteolytic maturation of its subunits. Furin cleaves the SCNN1A subunit, which results in a stepwise increase in the open probability of the channel due to the release of an inhibitory tract. BPIFA1, which is recruited by the SCNN1B subunit, prevents the proteolytic activation of ENaC. N-glycosylated. |
| Function | This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis. ENaC operates in epithelial tissues, where it mediates the electrodiffusion of sodium ions from extracellular fluid through the apical membrane of cells, with water following osmotically. It plays a key role in maintaining sodium homeostasis through electrogenic sodium reabsorption in the kidneys. Additionally, ENaC is essential for airway surface liquid homeostasis, which is crucial for proper mucus clearance. |
| Protein Name | Epithelial Sodium Channel Subunit AlphaAlpha-EnacEpithelial Na(+ Channel Subunit AlphaAlpha-NachAmiloride-Sensitive Sodium Channel Subunit AlphaNonvoltage-Gated Sodium Channel 1 Subunit AlphaScnea |
| Database Links | Reactome: R-MMU-2672351Reactome: -MMU-9730628 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinCell ProjectionCiliumCytoplasmic GranuleCytoplasmCytoplasmic VesicleSecretory VesicleAcrosomeFlagellumIn The Oviduct And BronchusLocated On Cilia In Multi-Ciliated CellsIn Endometrial Non-Ciliated Epithelial CellsRestricted To Apical SurfacesIn EpidermisLocated Nearly Uniformly In The Cytoplasm In A Granular DistributionIn Sebaceous GlandsObserved Only In The Cytoplasmic Space In Between The Lipid VesiclesIn Eccrine Sweat GlandsMainly Located At The Apical Surface Of The Cells Facing The LumenIn SkinIn Arrector Pili Muscle Cells And In AdipocytesLocated In The Cytoplasm And Colocalized With Actin FibersIn SpermatogoniaSpermatocytes And Round SpermatidsLocated In The CytoplasmPrior To SpermiationLocation Shifts From The Cytoplasm To The Spermatid TailIn SpermatozoaLocalizes At The Acrosome And The Central Region Of The Sperm Flagellum |
| Alternative Antibody Names | Anti-Epithelial Sodium Channel Subunit Alpha antibodyAnti-Alpha-Enac antibodyAnti-Epithelial Na(+ Channel Subunit Alpha antibodyAnti-Alpha-Nach antibodyAnti-Amiloride-Sensitive Sodium Channel Subunit Alpha antibodyAnti-Nonvoltage-Gated Sodium Channel 1 Subunit Alpha antibodyAnti-Scnea antibodyAnti-Scnn1a antibody |
Information sourced from Uniprot.org
