Anti-SCN7A antibody (771-820) (STJ94333)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from human SCN7A. AA range:771-820
General Information
| Short Description | Rabbit polyclonal anti-Sodium channel protein type 7 subunit alpha (771-820) for use in WB and IHC in Human and Monkey samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC |
| Host | Rabbit |
| Reactivity | Human/Monkey |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-p 1:50-300 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SCN7A |
| Gene ID | 6332 |
| Uniprot ID | SCN7A_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from human SCN7A. AA range:771-820 |
| Immunogen Region | 771-820 |
| Specificity | Na+ CP type VII Alpha Polyclonal Antibody detects endogenous levels of Na+ CP type VII Alpha protein. |
Additional Info
| Tissue Specificity | Heart and uterus. |
| Function | Sodium leak channel functioning as an osmosensor regulating sodium ion levels in various tissues and organs. While most sodium channels are voltage-gated, SCN7A is not and lets sodium flow through membrane along its concentration gradient. In glial cells of the central nervous system, senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake through activation of nearby neurons to maintain appropriate sodium levels in the body. By mediating sodium influx into keratinocytes, also plays a role in skin barrier homeostasis. |
| Protein Name | Sodium Channel Protein Type 7 Subunit AlphaAtypical Sodium Channel Nav2.1Nax ChannelSodium Channel Protein Type Vii Subunit Alpha |
| Database Links | Reactome: R-HSA-445095Reactome: R-HSA-5576892 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Sodium Channel Protein Type 7 Subunit Alpha antibodyAnti-Atypical Sodium Channel Nav2.1 antibodyAnti-Nax Channel antibodyAnti-Sodium Channel Protein Type Vii Subunit Alpha antibodyAnti-SCN7A antibodyAnti-SCN6A antibody |
Information sourced from Uniprot.org