Anti-SCN3A antibody (C-Term) (STJ13102073)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from the c-terminal of human Sodium channel protein type 3 subunit alpha (SCN3A, Nav1.3) conjugated to an immunogenic carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-SCN3A (C-Term) for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20ยฐC for long term storage and refrigerated at 2-8ยฐC for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | SCN3A |
| Gene ID | 6328 |
| Uniprot ID | SCN3A_HUMAN |
| Immunogen | A synthetic peptide from the c-terminal of human Sodium channel protein type 3 subunit alpha (SCN3A, Nav1.3) conjugated to an immunogenic carrier protein was used as the antigen. |
| Immunogen Region | C-Term |
| Specificity | Specific for SCN3A. |
Additional Info
| Post Translational Modifications | May be ubiquitinated by NEDD4L.which would promote its endocytosis. Phosphorylation at Ser-1501 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents. |
| Function | Pore-forming subunit of Nav1.3, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. In some secretory cell types, it also participates in cell excitability through membrane depolarization and regulates cells responsiveness to stimuli triggering secretion. For instance, it controls the release of serotonin/5-hydroxytryptamine by enterochromaffin cells and is required for both glucagon- and glucose-induced insulin secretion in pancreatic endocrine cells. |
| Protein Name | Sodium Channel Protein Type 3 Subunit AlphaSodium Channel Protein Brain Iii Subunit AlphaSodium Channel Protein Type Iii Subunit AlphaVoltage-Gated Sodium Channel Subtype IiiVoltage-Gated Sodium Channel Subunit Alpha Nav1.3 |
| Database Links | Reactome: R-HSA-445095Reactome: R-HSA-5576892Reactome: R-HSA-9717207 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinBasal Cell MembraneIn Enterochromaffin CellsLocalized Highly AsymmetricallyAlmost Exclusively At The Basal Side |
| Alternative Antibody Names | Anti-Sodium Channel Protein Type 3 Subunit Alpha antibodyAnti-Sodium Channel Protein Brain Iii Subunit Alpha antibodyAnti-Sodium Channel Protein Type Iii Subunit Alpha antibodyAnti-Voltage-Gated Sodium Channel Subtype Iii antibodyAnti-Voltage-Gated Sodium Channel Subunit Alpha Nav1.3 antibodyAnti-SCN3A antibodyAnti-KIAA1356 antibodyAnti-NAC3 antibody |
Information sourced from Uniprot.org