Anti-SCN2A antibody (275-401) (STJ112589)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SCN2A (275-401) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SCN2A |
| Gene ID | 6326 |
| Uniprot ID | SCN2A_HUMAN |
| Immunogen Region | 275-401 |
| Immunogen Sequence | RNKCLQWPPDNSSFEINITS FFNNSLDGNGTTFNRTVSIF NWDEYIEDKSHFYFLEGQND ALLCGNSSDAGQCPEGYICV KAGRNPNYGYTSFDTFSWAF LSLFRLMTQDFWENLYQLTL RAAGKTY |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 275-401 of human SCN2A (NP_001035232.1). |
Additional Info
| Post Translational Modifications | May be ubiquitinated by NEDD4L.which would promote its endocytosis. Phosphorylation at Ser-1506 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents. Sumoylated at Lys-38. Sumoylation is induced by hypoxia, increases voltage-gated sodium current and mediates the early response to acute hypoxia in neurons. Sumoylated SCN2A is located at the cell membrane. |
| Function | Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Implicated in the regulation of hippocampal replay occurring within sharp wave ripples (SPW-R) important for memory. |
| Protein Name | Sodium Channel Protein Type 2 Subunit AlphaHbsc IiSodium Channel Protein Brain Ii Subunit AlphaSodium Channel Protein Type Ii Subunit AlphaVoltage-Gated Sodium Channel Subunit Alpha Nav1.2 |
| Database Links | Reactome: R-HSA-445095Reactome: R-HSA-5576892Reactome: R-HSA-9717207 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Sodium Channel Protein Type 2 Subunit Alpha antibodyAnti-Hbsc Ii antibodyAnti-Sodium Channel Protein Brain Ii Subunit Alpha antibodyAnti-Sodium Channel Protein Type Ii Subunit Alpha antibodyAnti-Voltage-Gated Sodium Channel Subunit Alpha Nav1.2 antibodyAnti-SCN2A antibodyAnti-HBA antibodyAnti-NAC2 antibodyAnti-SCN2A1 antibodyAnti-SCN2A2 antibody |
Information sourced from Uniprot.org