Anti-SCN1A antibody (C-Term) (STJ13102072)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from the c-terminal of Sodium channel protein type 1 subunit alpha (SCN1A, Nav1.1) conjugated to blue carrier protein was used as the antigen. The antigen is homologus in rat and human.
General Information
| Short Description | Rabbit polyclonal anti-SCN1A (C-Term) for use in IHC and WB in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | SCN1A |
| Gene ID | 6323 |
| Uniprot ID | SCN1A_HUMAN |
| Immunogen | A synthetic peptide from the c-terminal of Sodium channel protein type 1 subunit alpha (SCN1A, Nav1.1) conjugated to blue carrier protein was used as the antigen. The antigen is homologus in rat and human. |
| Immunogen Region | C-Term |
| Specificity | Specific for SCN1A. |
Additional Info
| Function | Pore-forming subunit of Nav1.1, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. By regulating the excitability of neurons, ensures that they respond appropriately to synaptic inputs, maintaining the balance between excitation and inhibition in brain neural circuits. Nav1.1 plays a role in controlling the excitability and action potential propagation from somatosensory neurons, thereby contributing to the sensory perception of mechanically-induced pain. |
| Protein Name | Sodium Channel Protein Type 1 Subunit AlphaSodium Channel Protein Brain I Subunit AlphaSodium Channel Protein Type I Subunit AlphaVoltage-Gated Sodium Channel Subunit Alpha Nav1.1 |
| Database Links | Reactome: R-HSA-445095Reactome: R-HSA-5576892 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Sodium Channel Protein Type 1 Subunit Alpha antibodyAnti-Sodium Channel Protein Brain I Subunit Alpha antibodyAnti-Sodium Channel Protein Type I Subunit Alpha antibodyAnti-Voltage-Gated Sodium Channel Subunit Alpha Nav1.1 antibodyAnti-SCN1A antibodyAnti-NAC1 antibodyAnti-SCN1 antibody |
Information sourced from Uniprot.org