| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SCG5 (27-176) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SCG5 |
| Gene ID: |
6447 |
| Uniprot ID: |
7B2_HUMAN |
| Immunogen Region: |
27-176 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 27-176 of human SCG5 (NP_001138229.1). |
| Immunogen Sequence: |
YSPRTPDRVSEADIQRLLHG VMEQLGIARPRVEYPAHQAM NLVGPQSIEGGAHEGLQHLG PFGNIPNIVAELTGDNIPKD FSEDQGYPDPPNPCPVGKTA DDGCLENTPDTAEFSREFQL HQHLFDPEHDYPGLGKWNKK LLYEKMKGGE |
| Post Translational Modifications | Proteolytically cleaved in the Golgi by a furin-like convertase to generate bioactive peptides. Sulfated on tyrosine residues. |
| Function | Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro. |
| Protein Name | Neuroendocrine Protein 7b2Pituitary PolypeptideSecretogranin VSecretogranin-5Secretory Granule Endocrine Protein I Cleaved Into - N-Terminal Peptide - C-Terminal Peptide |
| Cellular Localisation | SecretedNeuroendocrine And Endocrine Secretory Granules |
| Alternative Antibody Names | Anti-Neuroendocrine Protein 7b2 antibodyAnti-Pituitary Polypeptide antibodyAnti-Secretogranin V antibodyAnti-Secretogranin-5 antibodyAnti-Secretory Granule Endocrine Protein I Cleaved Into - N-Terminal Peptide - C-Terminal Peptide antibodyAnti-SCG5 antibodyAnti-SGNE1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
