| Post Translational Modifications | Proteolytically cleaved in the Golgi by a furin-like convertase to generate bioactive peptides. Sulfated on tyrosine residues. |
| Function | Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro. |
| Protein Name | Neuroendocrine Protein 7b2Pituitary PolypeptideSecretogranin VSecretogranin-5Secretory Granule Endocrine Protein I Cleaved Into - N-Terminal Peptide - C-Terminal Peptide |
| Cellular Localisation | SecretedNeuroendocrine And Endocrine Secretory Granules |
| Alternative Antibody Names | Anti-Neuroendocrine Protein 7b2 antibodyAnti-Pituitary Polypeptide antibodyAnti-Secretogranin V antibodyAnti-Secretogranin-5 antibodyAnti-Secretory Granule Endocrine Protein I Cleaved Into - N-Terminal Peptide - C-Terminal Peptide antibodyAnti-SCG5 antibodyAnti-SGNE1 antibody |
Information sourced from Uniprot.org
