| Function | Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF4, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently of SCAF4, also acts as a positive regulator of transcript elongation. |
| Protein Name | Sr-Related And Ctd-Associated Factor 8Cdc5l Complex-Associated Protein 7Rna-Binding Motif Protein 16 |
| Cellular Localisation | NucleusNucleus MatrixDetected In Granular Nuclear Foci Which Correspond To Sites Of Active Transcription |
| Alternative Antibody Names | Anti-Sr-Related And Ctd-Associated Factor 8 antibodyAnti-Cdc5l Complex-Associated Protein 7 antibodyAnti-Rna-Binding Motif Protein 16 antibodyAnti-SCAF8 antibodyAnti-CCAP7 antibodyAnti-KIAA1116 antibodyAnti-RBM16 antibody |
Information sourced from Uniprot.org
