| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SCAF8 |
| Gene ID: | 22828 |
| Uniprot ID: | SCAF8_HUMAN |
| Immunogen Region: | 572-634 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 572-634 of human SCAF8 (NP_055707.3). |
| Immunogen Sequence: | PWEKVKVDDLEGFAEGGMID QETVNTEWETVKSSEPVKET VQTTQSPTPVEKETVVTTQA EVF |
| Function | Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF4, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently of SCAF4, also acts as a positive regulator of transcript elongation. |
| Protein Name | Sr-Related And Ctd-Associated Factor 8 Cdc5l Complex-Associated Protein 7 Rna-Binding Motif Protein 16 |
| Cellular Localisation | Nucleus Nucleus Matrix Detected In Granular Nuclear Foci Which Correspond To Sites Of Active Transcription |
| Alternative Antibody Names | Anti-Sr-Related And Ctd-Associated Factor 8 antibody Anti-Cdc5l Complex-Associated Protein 7 antibody Anti-Rna-Binding Motif Protein 16 antibody Anti-SCAF8 antibody Anti-CCAP7 antibody Anti-KIAA1116 antibody Anti-RBM16 antibody |
Information sourced from Uniprot.org