Anti-SARS1 antibody (STJA0009488)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human SARS
General Information
| Short Description | Rabbit polyclonal anti-Serine--tRNA ligase, cytoplasmic synthetase for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SARS1 |
| Gene ID | 6301 |
| Uniprot ID | SYSC_HUMAN |
| Immunogen | Synthesized peptide derived from human SARS |
| Specificity | This antibody detects endogenous levels of SARS at Human, Mouse, Rat |
Additional Info
| Function | Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA. |
| Protein Name | Serine--Trna Ligase - CytoplasmicSeryl-Trna SynthetaseSerrsSeryl-Trna(Ser/Sec Synthetase |
| Database Links | Reactome: R-HSA-2408557Reactome: R-HSA-379716 |
| Cellular Localisation | CytoplasmNucleusPredominantly CytoplasmicBut A Minor Proportion Is Also Found In The Nucleus |
| Alternative Antibody Names | Anti-Serine--Trna Ligase - Cytoplasmic antibodyAnti-Seryl-Trna Synthetase antibodyAnti-Serrs antibodyAnti-Seryl-Trna(Ser/Sec Synthetase antibodyAnti-SARS1 antibodyAnti-SARS antibodyAnti-SERS antibody |
Information sourced from Uniprot.org