Anti-Sarcomeric alpha Actinin antibody [R04-4U7] (STJA0037035)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human Alpha actinin 2
General Information
| Short Description | Rabbit monoclonal anti-Sarcomeric alpha Actinin for use in WB, IHC-P and IP in Mouse, Rat and Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IP |
| Host | Rabbit |
| Reactivity | Mouse/Rat/Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R04-4U7 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IP 1:30 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | ACTN2 |
| Gene ID | 88 |
| Uniprot ID | ACTN2_HUMAN |
| Immunogen | A synthesized peptide derived from human Alpha actinin 2 |
Additional Info
| Tissue Specificity | Expressed in both skeletal and cardiac muscle. |
| Post Translational Modifications | Ubiquitinated by FBXL22, leading to proteasomal degradation. |
| Function | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| Protein Name | Alpha-Actinin-2Alpha-Actinin Skeletal Muscle Isoform 2F-Actin Cross-Linking Protein |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-373753Reactome: R-HSA-390522Reactome: R-HSA-438066Reactome: R-HSA-442982Reactome: R-HSA-5673001Reactome: R-HSA-9609736Reactome: R-HSA-9617324Reactome: R-HSA-9620244 |
| Cellular Localisation | CytoplasmMyofibrilSarcomereZ LineColocalizes With Myoz1 And Flnc At The Z-Lines Of Skeletal Muscle |
| Alternative Antibody Names | Anti-Alpha-Actinin-2 antibodyAnti-Alpha-Actinin Skeletal Muscle Isoform 2 antibodyAnti-F-Actin Cross-Linking Protein antibodyAnti-ACTN2 antibody |
Information sourced from Uniprot.org