| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RUNX1T1 (250-403) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RUNX1T1 |
| Gene ID: |
862 |
| Uniprot ID: |
MTG8_HUMAN |
| Immunogen Region: |
250-403 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 250-403 of human RUNX1T1 (NP_783552.1). |
| Immunogen Sequence: |
ENGFDREPLHSEHPSKRPCT ISPGQRYSPNNGLSYQPNGL PHPTPPPPQHYRLDDMAIAH HYRDSYRHPSHRDLRDRNRP MGLHGTRQEEMIDHRLTDRE WAEEWKHLDHLLNCIMDMVE KTRRSLTVLRRCQEADREEL NYWIRRYSDAEDLK |
| Tissue Specificity | Most abundantly expressed in brain. Lower levels in lung, heart, testis and ovary. |
| Function | Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Can repress the expression of MMP7 in a ZBTB33-dependent manner. Can repress transactivation mediated by TCF12. Acts as a negative regulator of adipogenesis. The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal. |
| Protein Name | Protein Cbfa2t1Cyclin-D-Related ProteinEight Twenty One ProteinProtein EtoProtein Mtg8Zinc Finger Mynd Domain-Containing Protein 2 |
| Cellular Localisation | NucleusColocalizes With Atn1 In Discrete Nuclear Dots |
| Alternative Antibody Names | Anti-Protein Cbfa2t1 antibodyAnti-Cyclin-D-Related Protein antibodyAnti-Eight Twenty One Protein antibodyAnti-Protein Eto antibodyAnti-Protein Mtg8 antibodyAnti-Zinc Finger Mynd Domain-Containing Protein 2 antibodyAnti-RUNX1T1 antibodyAnti-AML1T1 antibodyAnti-CBFA2T1 antibodyAnti-CDR antibodyAnti-ETO antibodyAnti-MTG8 antibodyAnti-ZMYND2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
