| Tissue Specificity | Broadly expressed, with highest levels in lung, testis, kidney and brain. |
| Post Translational Modifications | Phosphorylation on Tyr-389 and/or Tyr-400 is required for interaction with BMX and endosomal targeting. |
| Function | Activating adapter involved in cargo sorting from early/recycling endosomes. Regulates retrieval of proteins from endosomes to the trans-Golgi network through interaction with the dynein-dynactin complex. Dual effector of RAB4B and RAB14, mediates a cooperative interaction allowing endosomal tethering and fusion. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking. In oocytes, self-assembles to form a protein matrix which hold together endolysosomes, autophagosomes and proteasomes and generate non-membrane-bound compartments called endo-lysosomal vesicular assemblies (ELVAs). In immature oocytes, ELVAs sequester ubiquitinated protein aggregates and degrade them upon oocyte maturation. |
| Protein Name | Run And Fyve Domain-Containing Protein 1Fyve-Finger Protein Eip1La-Binding Protein 1Rab4-Interacting ProteinZinc Finger Fyve Domain-Containing Protein 12 |
| Database Links | Reactome: R-HSA-1660499 |
| Cellular Localisation | Early Endosome MembranePeripheral Membrane ProteinIn OocytesLocalizes In Non-Membrane-Bound Compartments Called Endo-Lysosomal Vesicular Assemblies (Elvas) |
| Alternative Antibody Names | Anti-Run And Fyve Domain-Containing Protein 1 antibodyAnti-Fyve-Finger Protein Eip1 antibodyAnti-La-Binding Protein 1 antibodyAnti-Rab4-Interacting Protein antibodyAnti-Zinc Finger Fyve Domain-Containing Protein 12 antibodyAnti-RUFY1 antibodyAnti-RABIP4 antibodyAnti-ZFYVE12 antibody |
Information sourced from Uniprot.org
