Anti-RTN3 antibody [10A8] (STJ98369)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2a
ImmunogenPurified recombinant fragment of Rtn-3 expressed in E. Coli.
General Information
| Short Description | Mouse monoclonal anti-Reticulon-3 for use in IHC, IF and ELISA in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF/ELISA |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 10A8 |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | IHC 1:200-1:1000ELISA 1:10000IF 1:50-200 |
| Formulation | Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RTN3 |
| Gene ID | 10313 |
| Uniprot ID | RTN3_HUMAN |
| Immunogen | Purified recombinant fragment of Rtn-3 expressed in E. Coli. |
| Specificity | Rtn-3 Monoclonal Antibody detects endogenous levels of Rtn-3 protein. |
Additional Info
| Function | May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules. Also acts as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition. (Microbial infection) Plays a positive role in viral replication and pathogenesis of enteroviruses. |
| Protein Name | Reticulon-3Homolog Of Asy ProteinHapNeuroendocrine-Specific Protein-Like 2Nsp-Like Protein 2Neuroendocrine-Specific Protein-Like IiNsp-Like Protein IiNsplii |
| Database Links | Reactome: R-HSA-8849932 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinGolgi Apparatus Membrane |
| Alternative Antibody Names | Anti-Reticulon-3 antibodyAnti-Homolog Of Asy Protein antibodyAnti-Hap antibodyAnti-Neuroendocrine-Specific Protein-Like 2 antibodyAnti-Nsp-Like Protein 2 antibodyAnti-Neuroendocrine-Specific Protein-Like Ii antibodyAnti-Nsp-Like Protein Ii antibodyAnti-Nsplii antibodyAnti-RTN3 antibodyAnti-ASYIP antibodyAnti-NSPL2 antibody |
Information sourced from Uniprot.org