| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RRP8 (100-200) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RRP8 |
| Gene ID: |
23378 |
| Uniprot ID: |
RRP8_HUMAN |
| Immunogen Region: |
100-200 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human RRP8 (NP_056139.1). |
| Immunogen Sequence: |
GPPCSDSEEEVERKKKCHKQ ALVGSDSAEDEKRKRKCQKH APINSAQHLDNVDQTGPKAW KGSTTNDPPKQSPGSTSPKP PHTLSRKQWRNRQKNKRRCK N |
| Function | Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown. |
| Protein Name | Ribosomal Rna-Processing Protein 8Cerebral Protein 1Nucleomethylin |
| Database Links | Reactome: R-HSA-427359 |
| Cellular Localisation | NucleusNucleolusLocalizes At Rdna Locus |
| Alternative Antibody Names | Anti-Ribosomal Rna-Processing Protein 8 antibodyAnti-Cerebral Protein 1 antibodyAnti-Nucleomethylin antibodyAnti-RRP8 antibodyAnti-KIAA0409 antibodyAnti-NML antibodyAnti-hucep-1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
