| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Ribonucleoside-diphosphate reductase subunit M2 B (Internal) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000ELISA 1:40000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RRM2B |
| Gene ID: | 50484 |
| Uniprot ID: | RIR2B_HUMAN |
| Immunogen Region: | Internal |
| Specificity: | p53R2 Polyclonal Antibody detects endogenous levels of p53R2 protein. |
| Immunogen: | Synthesized peptide derived from the Internal region of human p53R2. |
| Function | Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage. |
| Protein Name | Ribonucleoside-Diphosphate Reductase Subunit M2 BTp53-Inducible Ribonucleotide Reductase M2 BP53-Inducible Ribonucleotide Reductase Small Subunit 2-Like ProteinP53r2 |
| Database Links | Reactome: R-HSA-499943Reactome: R-HSA-5628897 |
| Cellular Localisation | CytoplasmNucleusTranslocates From Cytoplasm To Nucleus In Response To Dna Damage |
| Alternative Antibody Names | Anti-Ribonucleoside-Diphosphate Reductase Subunit M2 B antibodyAnti-Tp53-Inducible Ribonucleotide Reductase M2 B antibodyAnti-P53-Inducible Ribonucleotide Reductase Small Subunit 2-Like Protein antibodyAnti-P53r2 antibodyAnti-RRM2B antibodyAnti-P53R2 antibody |
Information sourced from Uniprot.org