| Tissue Specificity | Ubiquitously expressed with highest levels of expression in skeletal muscle, heart, and brain. |
| Post Translational Modifications | Polybiquitinated via 'Lys-63'-linked polyubiquitination by RNF152 in response to amino acid starvation: polyubiquitination of the GDP-bound inactive form by RNF152 promotes RRAGA inactivation and interaction with the GATOR1 complex. This does not affect RRAGA degradation. |
| Function | Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RagC/RRAGC or RagD/RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form: RagA/RRAGA is in its active form when GTP-bound RagA/RRAGA forms a complex with GDP-bound RagC/RRAGC (or RagD/RRAGD) and in an inactive form when GDP-bound RagA/RRAGA heterodimerizes with GTP-bound RagC/RRAGC (or RagD/RRAGD). In its GTP-bound active form, promotes the recruitment of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. (Microbial infection) May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death. |
| Protein Name | Ras-Related Gtp-Binding Protein ARag ARagaAdenovirus E3 14.7 Kda-Interacting Protein 1Fip-1 |
| Database Links | Reactome: R-HSA-1632852Reactome: R-HSA-165159Reactome: R-HSA-166208Reactome: R-HSA-380972Reactome: R-HSA-5628897Reactome: R-HSA-8866654Reactome: R-HSA-8943724Reactome: R-HSA-9639288 |
| Cellular Localisation | CytoplasmNucleusLysosome MembranePredominantly CytoplasmicRecruited To The Lysosome Surface By The Ragulator ComplexMay Shuttle Between The Cytoplasm And NucleusDepending On The Bound Nucleotide StateColocalizes In Vivo With Adenovirus E3-147k Mainly To The Cytoplasm Especially Near The Nuclear Membrane And In Discrete Foci On Or Near The Plasma Membrane |
| Alternative Antibody Names | Anti-Ras-Related Gtp-Binding Protein A antibodyAnti-Rag A antibodyAnti-Raga antibodyAnti-Adenovirus E3 14.7 Kda-Interacting Protein 1 antibodyAnti-Fip-1 antibodyAnti-RRAGA antibody |
Information sourced from Uniprot.org
