| Short Description : | Rabbit polyclonal RPS19BP1 (1-136) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RPS19BP1 |
| Gene ID: | 91582 |
| Uniprot ID: | AROS_HUMAN |
| Immunogen Region: | 1-136 |
| Immunogen Sequence: | MSAALLRRGLELLAASEAPR DPPGQAKPRGAPVKRPRKTK AIQAQKLRNSAKGKVPKSAL DEYRKRECRDHLRVNLKFLT RTRSTVAESVSQQILRQNRG RKACDRPVAKTKKKKAEGTV FTEEDFQKFQQEYFGS |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-136 of human RPS19BP1 (NP_919307.1). |
| Tissue Specificity | Widely expressed (at protein level). |
| Post Translational Modifications | Citrullinated by PADI4. |
| Function | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Acts as a chaperone that specifically mediates the integration of RPS19 in state post-A1. Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity. |
| Protein Name | Active Regulator Of Sirt140s Ribosomal Protein S19-Binding Protein 1Rps19-Binding Protein 1S19bp |
| Database Links | Reactome: R-HSA-3371453 |
| Cellular Localisation | NucleusNucleolus |
| Alternative Antibody Names | Anti-Active Regulator Of Sirt1 antibodyAnti-40s Ribosomal Protein S19-Binding Protein 1 antibodyAnti-Rps19-Binding Protein 1 antibodyAnti-S19bp antibodyAnti-RPS19BP1 antibodyAnti-AROS antibody |
Information sourced from Uniprot.org
