| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Human/Dog |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-RPGRIP1L (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:64000. WB: Approx 150kDa band observed in Human Brain (Cerebellum) lysates (calculated MW of 151kDa according to NP_056087.2). Recommended concentration: 0.3-1µg/ml. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | RPGRIP1L |
| Gene ID: | 23322 |
| Uniprot ID: | FTM_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_056087.2 |
| Immunogen Sequence: | DKENNKAKRDILK |
| Function | Negatively regulates signaling through the G-protein coupled thromboxane A2 receptor (TBXA2R). May be involved in mechanisms like programmed cell death, craniofacial development, patterning of the limbs, and formation of the left-right axis. Involved in the organization of apical junctions.the function is proposed to implicate a NPHP1-4-8 module. Does not seem to be strictly required for ciliogenesis. Involved in establishment of planar cell polarity such as in cochlear sensory epithelium and is proposed to implicate stabilization of disheveled proteins. Involved in regulation of proteasomal activity at the primary cilium probably implicating association with PSDM2. |
| Protein Name | Protein Fantom Nephrocystin-8 Rpgr-Interacting Protein 1-Like Protein Rpgrip1-Like Protein |
| Database Links | Reactome: R-HSA-5610787 Reactome: R-HSA-5620912 |
| Cellular Localisation | Cytoplasm Cytoskeleton Cilium Basal Body Cilium Axoneme Microtubule Organizing Center Centrosome Cell Junction Tight Junction In Cultured Renal Cells It Localizes Diffusely In The Cytoplasm But As Cells Approach Confluence It Accumulates To Basolateral Tight Junctions Localizes To The Ciliary Transition Zone |
| Alternative Antibody Names | Anti-Protein Fantom antibody Anti-Nephrocystin-8 antibody Anti-Rpgr-Interacting Protein 1-Like Protein antibody Anti-Rpgrip1-Like Protein antibody Anti-RPGRIP1L antibody Anti-FTM antibody Anti-KIAA1005 antibody Anti-NPHP8 antibody |
Information sourced from Uniprot.org