| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RPGRIP1 (400-580) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RPGRIP1 |
| Gene ID: |
57096 |
| Uniprot ID: |
RPGR1_HUMAN |
| Immunogen Region: |
400-580 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 400-580 of human RPGRIP1 (NP_065099.3). |
| Immunogen Sequence: |
ELIAEQLQQQVSQLQDQLDA ELEDKRKVLLELSREKAQNE DLKLEVTNILQKHKQEVELL QNAATISQPPDRQSEPATHP AVLQENTQIEPSEPKNQEEK KLSQVLNELQVSHAETTLEL EKTRDMLILQRKINVCYQEE LEAMMTKADNDNRDHKEKLE RLTRLLDLKNNRIKQLEGIL R |
| Tissue Specificity | Strong expression in retina, with weaker expression in testis. Expressed in other neurons such as amacrine cells. Colocalizes with RGPR in the outer segment of rod photoreceptors and cone outer segments. |
| Function | May function as scaffolding protein. Required for normal location of RPGR at the connecting cilium of photoreceptor cells. Required for normal disk morphogenesis and disk organization in the outer segment of photoreceptor cells and for survival of photoreceptor cells. |
| Protein Name | X-Linked Retinitis Pigmentosa Gtpase Regulator-Interacting Protein 1Rpgr-Interacting Protein 1 |
| Cellular Localisation | Cell ProjectionCiliumSituated Between The Axonemal Microtubules And The Plasma MembraneIn The Retinal Photoreceptor Cell LayerLocalizes At The Connecting CiliumA Thin Bridge Linking The Cell Body And The Light-Sensing Outer SegmentColocalizes With Rgpr In The Photoreceptor Connecting Cilium |
| Alternative Antibody Names | Anti-X-Linked Retinitis Pigmentosa Gtpase Regulator-Interacting Protein 1 antibodyAnti-Rpgr-Interacting Protein 1 antibodyAnti-RPGRIP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
