| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RPAP2 |
| Gene ID: | 79871 |
| Uniprot ID: | RPAP2_HUMAN |
| Immunogen Region: | 1-612 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-612 of human RPAP2 (Q8IXW5). |
| Immunogen Sequence: | MADFAGPSSAGRKAGAPRCS RKAAGTKQTSTLKQEDASKR KAELEAAVRKKIEFERKALH IVEQLLEENITEEFLMECGR FITPAHYSDVVDERSIVKLC GYPLCQKKLGIVPKQKYKIS TKTNKVYDITERKSFCSNFC YQASKFFEAQIPKTPVWVRE EERHPDFQLLKEEQSGHSGE EVQLCSKAIKTSDIDNPSHF EKQYESSSSSTHSDSSSDNE QDFVSSILPGNRPNSTNIR |
| Function | Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes. Downstream of EIF2AK3/PERK, dephosphorylates ERN1, a sensor for the endoplasmic reticulum unfolded protein response (UPR), to abort failed ER-stress adaptation and trigger apoptosis. |
| Protein Name | Putative Rna Polymerase Ii Subunit B1 Ctd Phosphatase Rpap2Rna Polymerase Ii-Associated Protein 2 |
| Database Links | Reactome: R-HSA-6807505 |
| Cellular Localisation | CytoplasmNucleusShuttles Between The Cytoplasm And The Nucleus In A Crm1-Dependent Manner |
| Alternative Antibody Names | Anti-Putative Rna Polymerase Ii Subunit B1 Ctd Phosphatase Rpap2 antibodyAnti-Rna Polymerase Ii-Associated Protein 2 antibodyAnti-RPAP2 antibodyAnti-C1orf82 antibody |
Information sourced from Uniprot.org