Anti-RP2 antibody [3901] (STJ400101)

SKU:
STJ400101

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Host: Mouse
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-RP2 is suitable for use in ELISA research applications.
Clonality: Monoclonal
Clone ID: 3901
Conjugation: Unconjugated
Isotype: IgG1
Formulation: 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
Purification: Purity accurate to greater than or equal to 95%
Concentration: 5.0 mg/ml (+/-10 %)
Storage Instruction: 12 months from manufacturing at 2°C. Temperature analysis:-70 °C, 21 days N/D-20 °C, 21 days OK +4 °C, 21 days OK +30 °C, 21 days OK +35 °C, 7 days OK +35 °C, 21 days Failed due to reduced antigen binding +45 °C, 3 days OK +45 °C, 7 days OK, some cha
Determination Method: Radioimmunoassay (RIA)
Immunoreactivity: 80–120 % compared to the reference sample in an FIA test
Gene Symbol: RP2
Gene ID: 6102
Uniprot ID: XRP2_HUMAN
Immunogen: Plasmodium falciparum histidine-rich protein 2 (HRP2)
Tissue Specificity Ubiquitous. Expressed in the rod and cone photoreceptors, extending from the tips of the outer segment (OS) through the inner segment (IS) and outer nuclear layer (ONL) and into the synaptic terminals of the outer plexiform layer (ONL). Also detected in the bipolar, horizontal and amacrine cells in the inner nuclear layer (INL), extending to the inner plexiform layer (IPL) and though the ganglion cell layer (GCL) and into the nerve fiber layer (NFL) (at protein level).
Post Translational Modifications Myristoylated on Gly-2.which may be required for membrane targeting. Palmitoylated on Cys-3.which may be required for plasma membrane targeting (Probable). Mutation of Cys-3 targets the protein to internal membranes.
Function Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane. Involved in localization of proteins, such as NPHP3, to the cilium membrane by inducing hydrolysis of GTP ARL3, leading to the release of UNC119 (or UNC119B). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. Acts as guanine nucleotide dissociation inhibitor towards ADP-ribosylation factor-like proteins.
Protein Name Protein Xrp2
Database Links Reactome: R-HSA-5624138
Cellular Localisation Cell Membrane
Lipid-Anchor
Cytoplasmic Side
Cell Projection
Cilium
Detected Predominantly At The Plasma Membrane Of Rod And Cone Photoreceptors
Not Detected In The Nucleus
Alternative Antibody Names Anti-Protein Xrp2 antibody
Anti-RP2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance