Anti-RNH1 antibody (273-323 aa) (STJ194975)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human RINI at the amino acid range 273-323
General Information
| Short Description | Rabbit polyclonal anti-Ribonuclease inhibitor (273-323 aa) for use in WB and IHC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RNH1 |
| Gene ID | 6050 |
| Uniprot ID | RINI_HUMAN |
| Immunogen | Synthesized peptide derived from the human RINI at the amino acid range 273-323 |
| Immunogen Region | 273-323 aa |
| Specificity | This antibody detects endogenous levels of RINI at Human/Mouse/Rat |
Additional Info
| Function | Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and angiogenin (ANG). May play a role in redox homeostasis. Required to inhibit the cytotoxic tRNA ribonuclease activity of ANG in the cytoplasm in absence of stress. Relocates to the nucleus in response to stress, relieving inhibition of ANG in the cytoplasm, and inhibiting the angiogenic activity of ANG in the nucleus. |
| Protein Name | Ribonuclease InhibitorPlacental Ribonuclease InhibitorPlacental Rnase InhibitorRibonuclease/Angiogenin Inhibitor 1Rai |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusLocalizes In The Cytoplasm In Absence Of StressTranslocates To The Nucleus In Response To Stress |
| Alternative Antibody Names | Anti-Ribonuclease Inhibitor antibodyAnti-Placental Ribonuclease Inhibitor antibodyAnti-Placental Rnase Inhibitor antibodyAnti-Ribonuclease/Angiogenin Inhibitor 1 antibodyAnti-Rai antibodyAnti-RNH1 antibodyAnti-PRI antibodyAnti-RNH antibody |
Information sourced from Uniprot.org