Anti-RNF220 antibody (218-268 aa) (STJ193597)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human RN220 at the amino acid range 218-268
General Information
| Short Description | Rabbit polyclonal anti-E3 ubiquitin-protein ligase RNF220 (218-268 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RNF220 |
| Gene ID | 55182 |
| Uniprot ID | RN220_HUMAN |
| Immunogen | Synthesized peptide derived from the human RN220 at the amino acid range 218-268 |
| Immunogen Region | 218-268 aa |
| Specificity | This antibody detects endogenous levels of RN220 at Human/Mouse |
Additional Info
| Post Translational Modifications | Auto-ubiquitinated.leads to proteasomal degradation. |
| Function | E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B. Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 promoting Wnt signaling. Plays a critical role in the regulation of nuclear lamina. |
| Protein Name | E3 Ubiquitin-Protein Ligase Rnf220Ring Finger Protein 220Ring-Type E3 Ubiquitin Transferase Rnf220 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Rnf220 antibodyAnti-Ring Finger Protein 220 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Rnf220 antibodyAnti-RNF220 antibodyAnti-C1orf164 antibody |
Information sourced from Uniprot.org