Anti-RNF183 antibody (4-54 aa) (STJ193824)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human RN183 at the amino acid range 4-54
General Information
| Short Description | Rabbit polyclonal anti-E3 ubiquitin-protein ligase RNF183 (4-54 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RNF183 |
| Gene ID | 138065 |
| Uniprot ID | RN183_HUMAN |
| Immunogen | Synthesized peptide derived from the human RN183 at the amino acid range 4-54 |
| Immunogen Region | 4-54 aa |
| Specificity | This antibody detects endogenous levels of RN183 at Human/Mouse |
Additional Info
| Post Translational Modifications | Autoubiquitinated (in vitro). |
| Function | Acts as an E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Triggers apoptosis in response to prolonged ER stress by mediating the polyubiquitination and subsequent proteasomal degradation of BCL2L1. May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling. |
| Protein Name | E3 Ubiquitin-Protein Ligase Rnf183 |
| Database Links | |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Iv Membrane ProteinEndoplasmic ReticulumGolgi ApparatusCis-Golgi Network MembraneLysosome Membrane |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Rnf183 antibodyAnti-RNF183 antibody |
Information sourced from Uniprot.org