| Host: |
Rabbit |
| Applications: |
WB/IF/ICC/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000IF/ICC:1:20-1:50ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RNF166 |
| Gene ID: |
115992 |
| Uniprot ID: |
RN166_HUMAN |
| Immunogen Region: |
1-237 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-237 of human RNF166 (NP_849163.1). |
| Immunogen Sequence: |
MAMFRSLVASAQQRQPPAGP AGGDSGLEAQYTCPICLEVY HRPVAIGSCGHTFCGECLQP CLQVPSPLCPLCRLPFDPKK VDKATHVEKQLSSYKAPCRG CNKKVTLAKMRVHISSCLKV QEQMANCPKFVPVVPTSQPI PSNIPNRSTFACPYCGARNL DQQELVKHCVESHRSDPNRV VCPICSAMPWGDPSYKSANF LQHLLHRHKFSYDTFVDYSI DEEAAFQAALALSLSEN |
| Function | E3 ubiquitin-protein ligase that promotes the ubiquitination of different substrates. In turn, participates in different biological processes including interferon production or autophagy. Plays a role in the activation of RNA virus-induced interferon-beta production by promoting the ubiquitination of TRAF3 and TRAF6. Also plays a role in the early recruitment of autophagy adapters to bacteria. Mediates 'Lys-29' and 'Lys-33'-linked ubiquitination of SQSTM1 leading to xenophagic targeting of bacteria and inhibition of their replication. |
| Protein Name | E3 Ubiquitin-Protein Ligase Rnf166Ring Finger Protein 166Ring-Type E3 Ubiquitin Transferase Rnf166 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Rnf166 antibodyAnti-Ring Finger Protein 166 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Rnf166 antibodyAnti-RNF166 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
