| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IF/ICC:1:20-1:50ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RNF166 |
| Gene ID: | 115992 |
| Uniprot ID: | RN166_HUMAN |
| Immunogen Region: | 1-237 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-237 of human RNF166 (NP_849163.1). |
| Immunogen Sequence: | MAMFRSLVASAQQRQPPAGP AGGDSGLEAQYTCPICLEVY HRPVAIGSCGHTFCGECLQP CLQVPSPLCPLCRLPFDPKK VDKATHVEKQLSSYKAPCRG CNKKVTLAKMRVHISSCLKV QEQMANCPKFVPVVPTSQPI PSNIPNRSTFACPYCGARNL DQQELVKHCVESHRSDPNRV VCPICSAMPWGDPSYKSANF LQHLLHRHKFSYDTFVDYSI DEEAAFQAALALSLSEN |
| Function | E3 ubiquitin-protein ligase that promotes the ubiquitination of different substrates. In turn, participates in different biological processes including interferon production or autophagy. Plays a role in the activation of RNA virus-induced interferon-beta production by promoting the ubiquitination of TRAF3 and TRAF6. Also plays a role in the early recruitment of autophagy adapters to bacteria. Mediates 'Lys-29' and 'Lys-33'-linked ubiquitination of SQSTM1 leading to xenophagic targeting of bacteria and inhibition of their replication. |
| Protein Name | E3 Ubiquitin-Protein Ligase Rnf166Ring Finger Protein 166Ring-Type E3 Ubiquitin Transferase Rnf166 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Rnf166 antibodyAnti-Ring Finger Protein 166 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Rnf166 antibodyAnti-RNF166 antibody |
Information sourced from Uniprot.org
