| Short Description : | Rabbit polyclonal RND1 (187-206) antibody for use in WB, IF, ICC and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RND1 |
| Gene ID: | 27289 |
| Uniprot ID: | RND1_HUMAN |
| Immunogen Region: | 187-206 |
| Immunogen Sequence: | LSTLMELSHQKQAPISYEQG CAIAKQLGAEIYLEGSAFTS EKSIHSIFRTASMLCLNKPS PLPQKSPVRSLSKRLLHLPS RSELISSTFKKEKAKSCSIM |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 133-232 of human RND1 (NP_055285.1). |
| Tissue Specificity | Mostly expressed in brain and liver. |
| Function | Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments. |
| Protein Name | Rho-Related Gtp-Binding Protein Rho6Rho Family Gtpase 1Rnd1 |
| Database Links | Reactome: R-HSA-399955Reactome: R-HSA-416550Reactome: R-HSA-416572Reactome: R-HSA-9696273 |
| Cellular Localisation | Cell MembraneLipid-AnchorCytoplasmic SideCytoplasmCytoskeleton |
| Alternative Antibody Names | Anti-Rho-Related Gtp-Binding Protein Rho6 antibodyAnti-Rho Family Gtpase 1 antibodyAnti-Rnd1 antibodyAnti-RND1 antibodyAnti-RHO6 antibody |
Information sourced from Uniprot.org
