Anti-RMI1 antibody (1-350) (STJ25361)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal RMI1 (1-350) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RMI1 |
| Gene ID | 80010 |
| Uniprot ID | RMI1_HUMAN |
| Immunogen Region | 1-350 |
| Immunogen Sequence | MNVTSIALRAETWLLAAWHV KVPPMWLEACINWIQEENNN VNLSQAQMNKQVFEQWLLTD LRDLEHPLLPDGILEIPKGE LNGFYALQINSLVDVSQPAY SQIQKLRGKNTTNDLVTAEA QVTPKPWEAKPSRMLMLQLT DGIVQIQGMEYQPIPILHSD LPPGTKILIYGNISFRLGVL LLKPENVKVLGGEVDALLEE YAQEKVLARLIGEPDLVVSV IPNNSNENIPRVTDVLDPA |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human RMI1 (NP_079221.2). |
Additional Info
| Function | Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability. |
| Protein Name | Recq-Mediated Genome Instability Protein 1Blm-Associated Protein Of 75 KdaBlap75Faap75 |
| Database Links | Reactome: R-HSA-5685938Reactome: R-HSA-5685942Reactome: R-HSA-5693554Reactome: R-HSA-5693568Reactome: R-HSA-5693579Reactome: R-HSA-5693607Reactome: R-HSA-5693616Reactome: R-HSA-6804756Reactome: R-HSA-69473Reactome: R-HSA-9701192Reactome: R-HSA-9704331Reactome: R-HSA-9704646Reactome: R-HSA-9709570Reactome: R-HSA-9709603 |
| Cellular Localisation | NucleusForms Foci In Response To Dna Damage |
| Alternative Antibody Names | Anti-Recq-Mediated Genome Instability Protein 1 antibodyAnti-Blm-Associated Protein Of 75 Kda antibodyAnti-Blap75 antibodyAnti-Faap75 antibodyAnti-RMI1 antibodyAnti-C9orf76 antibody |
Information sourced from Uniprot.org