| Host: | Rabbit |
| Applications: | IHC/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-RIC3 (320-369 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Lyophilised |
| Purification: | IgG purified |
| Dilution Range: | IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | RIC3 |
| Gene ID: | 79608 |
| Uniprot ID: | RIC3_HUMAN |
| Immunogen Region: | 320-369 aa |
| Specificity: | Specific for RIC3. |
| Immunogen: | A synthetic peptide from aa region 320-369 of human RIC3 conjugated to blue carrier protein was used as the antigen. |
| Function | Molecular chaperone which facilitates proper subunit assembly and surface trafficking of alpha-7 (CHRNA7) and alpha-8 (CHRNA8) nicotinic acetylcholine receptors. May also promote functional expression of homomeric serotoninergic 5-HT3 receptors, and of heteromeric acetylcholine receptors alpha-3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4. |
| Protein Name | Protein Ric-3Resistant To Inhibitor Of Cholinesterase 3 |
| Cellular Localisation | Isoform 1: Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinIsoform 2: Endoplasmic Reticulum MembraneGolgi Apparatus Membrane |
| Alternative Antibody Names | Anti-Protein Ric-3 antibodyAnti-Resistant To Inhibitor Of Cholinesterase 3 antibodyAnti-RIC3 antibodyAnti-UNQ720 antibodyAnti-PRO1385 antibody |
Information sourced from Uniprot.org