| Tissue Specificity | Highly expressed in cerebellum, cerebrum, heart, skeletal muscle, placenta, pancreatic islet and testis. Detected at lower levels in colon, kidney, small intestine and lung. |
| Post Translational Modifications | N-glycosylated. |
| Function | Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. |
| Protein Name | Inactive Rhomboid Protein 1Irhom1Epidermal Growth Factor Receptor-Related ProteinRhomboid 5 Homolog 1Rhomboid Family Member 1P100hrho |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinGolgi Apparatus MembranePredominantly Localized In The Endoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Inactive Rhomboid Protein 1 antibodyAnti-Irhom1 antibodyAnti-Epidermal Growth Factor Receptor-Related Protein antibodyAnti-Rhomboid 5 Homolog 1 antibodyAnti-Rhomboid Family Member 1 antibodyAnti-P100hrho antibodyAnti-RHBDF1 antibodyAnti-C16orf8 antibodyAnti-DIST1 antibodyAnti-IRHOM1 antibody |
Information sourced from Uniprot.org
