| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RGS7 (1-300) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RGS7 |
| Gene ID: |
6000 |
| Uniprot ID: |
RGS7_HUMAN |
| Immunogen Region: |
1-300 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human RGS7 (NP_002915.3). |
| Immunogen Sequence: |
MAQGNNYGQTSNGVADESPN MLVYRKMEDVIARMQDEKNG IPIRTVKSFLSKIPSVFSGS DIVQWLIKNLTIEDPVEALH LGTLMAAHGYFFPISDHVLT LKDDGTFYRFQTPYFWPSNC WEPENTDYAVYLCKRTMQNK ARLELADYEAESLARLQRAF ARKWEFIFMQAEAQAKVDKK RDKIERKILDSQERAFWDVH RPVPGCVNTTEVDIKKSSRM RNPHKTRKSVYGLQNDIRS |
| Post Translational Modifications | Palmitoylated. Ubiquitinated, leading to rapid proteasomal degradation. Phosphorylation and subsequent interaction with 14-3-3 proteins inhibits GAP activity. |
| Function | GTPase activator component of the RGS7-GNB5 complex that regulates G protein-coupled receptor signaling cascades. The RGS7-GNB5 complex acts as an inhibitor signal transduction by promoting the GTPase activity of G protein alpha subunits, such as GNAO1, thereby driving them into their inactive GDP-bound form. May play a role in synaptic vesicle exocytosis (Probable). Glycine-dependent regulation of the RGS7-GNB5 complex by GPR158 affects mood and cognition via its ability to regulate neuronal excitability in L2/L3 pyramidal neurons of the prefrontal cortex. Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling. |
| Protein Name | Regulator Of G-Protein Signaling 7Rgs7 |
| Database Links | Reactome: R-HSA-418594Reactome: R-HSA-6814122 |
| Cellular Localisation | CytoplasmCytosolCell MembraneMembranePeripheral Membrane ProteinCytoplasmic SideInteraction With Pkd1 Promotes Location At The Cell MembraneInteraction With Rgs7bp Promotes Location At The Cell Membrane |
| Alternative Antibody Names | Anti-Regulator Of G-Protein Signaling 7 antibodyAnti-Rgs7 antibodyAnti-RGS7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
