• Immunohistochemistry analysis of paraffin-embedded human esophagus using RGS2 Rabbit polyclonal antibody (STJ11103885) at dilution of 1:100 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of paraffin-embedded human colon using RGS2 Rabbit polyclonal antibody (STJ11103885) at dilution of 1:100 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of paraffin-embedded human breast cancer using RGS2 Rabbit polyclonal antibody (STJ11103885) at dilution of 1:100 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.

Anti-RGS2 antibody (1-211) (STJ11103885)

SKU:
STJ11103885

£112.50 - £522.50
Current Stock:
Host: Rabbit
Applications: WB/IHC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Regulator Of G-Protein Signaling 2 (1-211) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IHC-P 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: RGS2
Gene ID: 5997
Uniprot ID: RGS2_HUMAN
Immunogen Region: 1-211
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-211 of human RGS2 (NP_002914.1).
Immunogen Sequence: MQSAMFLAVQHDCRPMDKSA GSGHKSEEKREKMKRTLLKD WKTRLSYFLQNSSTPGKPKT GKKSKQQAFIKPSPEEAQLW SEAFDELLASKYGLAAFRAF LKSEFCEENIEFWLACEDFK KTKSPQKLSSKARKIYTDFI EKEAPKEINIDFQTKTLIAQ NIQEATSGCFTTAQKRVYSL MENNSYPRFLESEFYQDLCK KPQITTEPHAT
Tissue Specificity Expressed in acute myelogenous leukemia (AML) and in acute lymphoblastic leukemia (ALL).
Post Translational Modifications Phosphorylated by protein kinase C. Phosphorylation by PRKG1 leads to activation of RGS2 activity.
Function Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. It is involved in the negative regulation of the angiotensin-activated signaling pathway. Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein.
Protein Name Regulator Of G-Protein Signaling 2
Rgs2
Cell Growth-Inhibiting Gene 31 Protein
G0/G1 Switch Regulatory Protein 8
Database Links Reactome: R-HSA-416476
Cellular Localisation Isoform 1: Cell Membrane
Cytoplasm
Nucleus
Nucleolus
Isoform 2: Cell Membrane
Isoform 3: Cell Membrane
Isoform 4: Cell Membrane
Mitochondrion
Alternative Antibody Names Anti-Regulator Of G-Protein Signaling 2 antibody
Anti-Rgs2 antibody
Anti-Cell Growth-Inhibiting Gene 31 Protein antibody
Anti-G0/G1 Switch Regulatory Protein 8 antibody
Anti-RGS2 antibody
Anti-G0S8 antibody
Anti-GIG31 antibody

Information sourced from Uniprot.org

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