| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Regulator Of G-Protein Signaling 2 (1-211) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RGS2 |
| Gene ID: |
5997 |
| Uniprot ID: |
RGS2_HUMAN |
| Immunogen Region: |
1-211 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-211 of human RGS2 (NP_002914.1). |
| Immunogen Sequence: |
MQSAMFLAVQHDCRPMDKSA GSGHKSEEKREKMKRTLLKD WKTRLSYFLQNSSTPGKPKT GKKSKQQAFIKPSPEEAQLW SEAFDELLASKYGLAAFRAF LKSEFCEENIEFWLACEDFK KTKSPQKLSSKARKIYTDFI EKEAPKEINIDFQTKTLIAQ NIQEATSGCFTTAQKRVYSL MENNSYPRFLESEFYQDLCK KPQITTEPHAT |
| Tissue Specificity | Expressed in acute myelogenous leukemia (AML) and in acute lymphoblastic leukemia (ALL). |
| Post Translational Modifications | Phosphorylated by protein kinase C. Phosphorylation by PRKG1 leads to activation of RGS2 activity. |
| Function | Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. It is involved in the negative regulation of the angiotensin-activated signaling pathway. Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein. |
| Protein Name | Regulator Of G-Protein Signaling 2Rgs2Cell Growth-Inhibiting Gene 31 ProteinG0/G1 Switch Regulatory Protein 8 |
| Database Links | Reactome: R-HSA-416476 |
| Cellular Localisation | Isoform 1: Cell MembraneCytoplasmNucleusNucleolusIsoform 2: Cell MembraneIsoform 3: Cell MembraneIsoform 4: Cell MembraneMitochondrion |
| Alternative Antibody Names | Anti-Regulator Of G-Protein Signaling 2 antibodyAnti-Rgs2 antibodyAnti-Cell Growth-Inhibiting Gene 31 Protein antibodyAnti-G0/G1 Switch Regulatory Protein 8 antibodyAnti-RGS2 antibodyAnti-G0S8 antibodyAnti-GIG31 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
