| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IHC-P:1:100-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | REN |
| Gene ID: | 5972 |
| Uniprot ID: | RENI_HUMAN |
| Immunogen Region: | 250-406 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 250-406 of human Renin (NP_000528.1). |
| Immunogen Sequence: | QHYEGNFHYINLIKTGVWQI QMKGVSVGSSTLLCEDGCLA LVDTGASYISGSTSSIEKLM EALGAKKRLFDYVVKCNEGP TLPDISFHLGGKEYTLTSAD YVFQESYSSKKLCTLAIHAM DIPPPTGPTWALGATFIRKF YTEFDRRNNRIGFALAR |
| Function | Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. |
| Protein Name | ReninAngiotensinogenase |
| Database Links | Reactome: R-HSA-2022377 |
| Cellular Localisation | SecretedMembraneAssociated To Membranes Via Binding To Atp6ap2 |
| Alternative Antibody Names | Anti-Renin antibodyAnti-Angiotensinogenase antibodyAnti-REN antibody |
Information sourced from Uniprot.org