| Host: | Rabbit |
| Applications: | IF/IHC/IP/WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit monoclonal antibody anti-Recombinant-Ubiquitin-Conjugating Enzyme E2 C is suitable for use in Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Clonality : | Monoclonal |
| Clone ID : | RM1D06 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.01M PBS |
| Purification: | Protein A/G purified from cell culture supernatant |
| Dilution Range: | IF: 1:50-1:200 |
| Storage Instruction: | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
| Gene Symbol: | UBE2C |
| Gene ID: | 11065 |
| Uniprot ID: | UBE2C_HUMAN |
| Function | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit. |
| Protein Name | Ubiquitin-Conjugating Enzyme E2 C(E3-Independent E2 Ubiquitin-Conjugating Enzyme CE2 Ubiquitin-Conjugating Enzyme CUbch10Ubiquitin Carrier Protein CUbiquitin-Protein Ligase C |
| Database Links | Reactome: R-HSA-141430Reactome: R-HSA-174048Reactome: R-HSA-174084Reactome: R-HSA-174154Reactome: R-HSA-174178Reactome: R-HSA-174184Reactome: R-HSA-176407Reactome: R-HSA-176408Reactome: R-HSA-176409Reactome: R-HSA-176412Reactome: R-HSA-179409Reactome: R-HSA-2467813Reactome: R-HSA-2559582Reactome: R-HSA-68867Reactome: R-HSA-69017Reactome: R-HSA-8853884Reactome: R-HSA-8866652Reactome: R-HSA-9687136Reactome: R-HSA-983168 |
| Alternative Antibody Names | Anti-Ubiquitin-Conjugating Enzyme E2 C antibodyAnti-(E3-Independent E2 Ubiquitin-Conjugating Enzyme C antibodyAnti-E2 Ubiquitin-Conjugating Enzyme C antibodyAnti-Ubch10 antibodyAnti-Ubiquitin Carrier Protein C antibodyAnti-Ubiquitin-Protein Ligase C antibodyAnti-UBE2C antibodyAnti-UBCH10 antibody |
Information sourced from Uniprot.org