Anti-Recombinant-TXNIP antibody [RM2K19] (STJA0025884)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Thioredoxin-Interacting Protein for use in FC, IF, IHC and WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC/IF/IHC/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM2K19 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | FCM: 1:20-1:100, IF: 1:50-1:200, IHC: 1:100-1:200, WB: 1:1000-1:2000 |
| Formulation | 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium Azide |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | TXNIP |
| Gene ID | 10628 |
| Uniprot ID | TXNIP_HUMAN |
Additional Info
| Function | May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1). |
| Protein Name | Thioredoxin-Interacting ProteinThioredoxin-Binding Protein 2Vitamin D3 Up-Regulated Protein 1 |
| Database Links | Reactome: R-HSA-844456Reactome: R-HSA-9617629Reactome: R-HSA-9660826Reactome: R-HSA-9707564 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Thioredoxin-Interacting Protein antibodyAnti-Thioredoxin-Binding Protein 2 antibodyAnti-Vitamin D3 Up-Regulated Protein 1 antibodyAnti-TXNIP antibodyAnti-VDUP1 antibody |
Information sourced from Uniprot.org