Anti-Recombinant-NOLC1 antibody [RM2F81] (STJA0025550)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Nucleolar And Coiled-Body Phosphoprotein 1 for use in IF, IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IF/IHC/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM2F81 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | IF: 1:50-1:200, IHC: 1:100-1:200, WB: 1:1000-1:2000 |
| Formulation | 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium Azide |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | NOLC1 |
| Gene ID | 9221 |
| Uniprot ID | NOLC1_HUMAN |
Additional Info
| Function | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification. Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification. Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus. It has intrinsic GTPase and ATPase activities. |
| Protein Name | Nucleolar And Coiled-Body Phosphoprotein 1140 Kda Nucleolar PhosphoproteinNopp140Hepatitis C Virus Ns5a-Transactivated Protein 13Hcv Ns5a-Transactivated Protein 13Nucleolar 130 Kda ProteinNucleolar Phosphoprotein P130 |
| Database Links | |
| Cellular Localisation | NucleusNucleolusCytoplasmShuttles Between The Nucleolus And The CytoplasmAt Telophase It Begins To Assemble Into Granular-Like Pre-Nucleolar Bodies Which Are Subsequently Relocated To Nucleoli At The Early G1-Phase |
| Alternative Antibody Names | Anti-Nucleolar And Coiled-Body Phosphoprotein 1 antibodyAnti-140 Kda Nucleolar Phosphoprotein antibodyAnti-Nopp140 antibodyAnti-Hepatitis C Virus Ns5a-Transactivated Protein 13 antibodyAnti-Hcv Ns5a-Transactivated Protein 13 antibodyAnti-Nucleolar 130 Kda Protein antibodyAnti-Nucleolar Phosphoprotein P130 antibodyAnti-NOLC1 antibodyAnti-KIAA0035 antibodyAnti-NS5ATP13 antibody |
Information sourced from Uniprot.org