Anti-Recombinant-NFATC1 antibody [RM1G57] (STJA0023249)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Nuclear Factor Of Activated T-Cells-Cytoplasmic 1 for use in FC, IF and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC/IF/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM1G57 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | FCM: 1:20-1:100 |
| Formulation | 0.01M PBS |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | NFATC1 |
| Gene ID | 4772 |
| Uniprot ID | NFAC1_HUMAN |
Additional Info
| Post Translational Modifications | Phosphorylated by NFATC-kinase and GSK3B.phosphorylation induces NFATC1 nuclear exit and dephosphorylation by calcineurin promotes nuclear import. Phosphorylation by PKA and DYRK2 negatively modulates nuclear accumulation, and promotes subsequent phosphorylation by GSK3B or casein kinase 1. |
| Function | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells. Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function. |
| Protein Name | Nuclear Factor Of Activated T-Cells - Cytoplasmic 1Nf-Atc1Nfatc1Nfat Transcription Complex Cytosolic ComponentNf-AtcNfatc |
| Database Links | Reactome: R-HSA-2025928Reactome: R-HSA-2871809Reactome: R-HSA-4086398Reactome: R-HSA-5607763 |
| Cellular Localisation | CytoplasmNucleusCytoplasmic For The Phosphorylated Form And Nuclear After Activation That Is Controlled By Calcineurin-Mediated DephosphorylationRapid Nuclear Exit Of Nfatc Is Thought To Be One Mechanism By Which Cells Distinguish Between Sustained And Transient Calcium SignalsTranslocation To The Nucleus Is Increased In The Presence Of Calcium In Pre-OsteoblastsThe Subcellular Localization Of Nfatc Plays A Key Role In The Regulation Of Gene TranscriptionNuclear Translocation Of Nfatc1 Is Enhanced In The Presence Of Tnfsf11Nuclear Translocation Is Decreased In The Presence Of Fbn1 Which Can Bind And Sequester Tnfsf11 |
| Alternative Antibody Names | Anti-Nuclear Factor Of Activated T-Cells - Cytoplasmic 1 antibodyAnti-Nf-Atc1 antibodyAnti-Nfatc1 antibodyAnti-Nfat Transcription Complex Cytosolic Component antibodyAnti-Nf-Atc antibodyAnti-Nfatc antibodyAnti-NFATC1 antibodyAnti-NFAT2 antibodyAnti-NFATC antibody |
Information sourced from Uniprot.org