Function | Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway. Involved in endothelial cell proliferation and angiogenesis. |
Protein Name | Myeloid-Derived Growth FactorMydgf |
Database Links | Reactome: R-HSA-381038 |
Cellular Localisation | SecretedEndoplasmic Reticulum-Golgi Intermediate CompartmentEndoplasmic ReticulumGolgi ApparatusThe C-Terminal Rtel Motif May Provide Retention In The Endoplasmic Reticulum |
Alternative Antibody Names | Anti-Myeloid-Derived Growth Factor antibodyAnti-Mydgf antibodyAnti-MYDGF antibodyAnti-C19orf10 antibody |
Information sourced from Uniprot.org