Anti-Recombinant-MAP3K11 antibody [RM2H12] (STJA0025679)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Mitogen-Activated Protein Kinase Kinase Kinase 11 for use in IF and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IF/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM2H12 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | IF: 1:50-1:200, WB: 1:500-1:1000 |
| Formulation | 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium Azide |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | MAP3K11 |
| Gene ID | 4296 |
| Uniprot ID | M3K11_HUMAN |
Additional Info
| Post Translational Modifications | Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Thr-277 is likely to be the main autophosphorylation site. Phosphorylation of Ser-555 and Ser-556 is induced by CDC42. |
| Function | Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle. |
| Protein Name | Mitogen-Activated Protein Kinase Kinase Kinase 11Mixed Lineage Kinase 3Src-Homology 3 Domain-Containing Proline-Rich Kinase |
| Database Links | Reactome: R-HSA-5673000Reactome: R-HSA-6802946Reactome: R-HSA-6802955Reactome: R-HSA-9013148Reactome: R-HSA-9013408Reactome: R-HSA-9013424Reactome: R-HSA-9649948 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeLocation Is Cell Cycle Dependent |
| Alternative Antibody Names | Anti-Mitogen-Activated Protein Kinase Kinase Kinase 11 antibodyAnti-Mixed Lineage Kinase 3 antibodyAnti-Src-Homology 3 Domain-Containing Proline-Rich Kinase antibodyAnti-MAP3K11 antibodyAnti-MLK3 antibodyAnti-PTK1 antibodyAnti-SPRK antibody |
Information sourced from Uniprot.org