Anti-Recombinant-IRF9 antibody [RM2B83] (STJA0025156)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Interferon Regulatory Factor 9 for use in FC, IF and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC/IF/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM2B83 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | FCM: 1:20-1:100, IF: 1:50-1:200, WB: 1:1000-1:2000 |
| Formulation | 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium Azide |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | IRF9 |
| Gene ID | 10379 |
| Uniprot ID | IRF9_HUMAN |
Additional Info
| Function | Transcription factor that plays an essential role in anti-viral immunity. It mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. |
| Protein Name | Interferon Regulatory Factor 9Irf-9Ifn-Alpha-Responsive Transcription Factor SubunitIsgf3 P48 SubunitInterferon-Stimulated Gene Factor 3 GammaIsgf-3 GammaTranscriptional Regulator Isgf3 Subunit Gamma |
| Database Links | Reactome: R-HSA-877300Reactome: R-HSA-909733 |
| Cellular Localisation | CytoplasmNucleusTranslocated Into The Nucleus Upon Activation By Ifn-Alpha/Beta |
| Alternative Antibody Names | Anti-Interferon Regulatory Factor 9 antibodyAnti-Irf-9 antibodyAnti-Ifn-Alpha-Responsive Transcription Factor Subunit antibodyAnti-Isgf3 P48 Subunit antibodyAnti-Interferon-Stimulated Gene Factor 3 Gamma antibodyAnti-Isgf-3 Gamma antibodyAnti-Transcriptional Regulator Isgf3 Subunit Gamma antibodyAnti-IRF9 antibodyAnti-ISGF3G antibody |
Information sourced from Uniprot.org