Anti-Recombinant-CASP5 antibody [RM1Y43] (STJA0024819)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Caspase-5 for use in IF, IHC, IP and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IF/IHC/IP/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM1Y43 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | IF: 1:50-1:200 |
| Formulation | 0.01M PBS |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | CASP5 |
| Gene ID | 838 |
| Uniprot ID | CASP5_HUMAN |
Additional Info
| Post Translational Modifications | The two subunits are derived from the precursor sequence by an autocatalytic mechanism. |
| Function | Thiol protease that acts as a mediator of programmed cell death. Initiates pyroptosis, a programmed lytic cell death pathway through cleavage of Gasdermin-D (GSDMD): cleavage releases the N-terminal gasdermin moiety (Gasdermin-D, N-terminal) that binds to membranes and forms pores, triggering pyroptosis. Also mediates cleavage and maturation of IL18. Cleavage of GSDMD and IL18 is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP4. During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation. |
| Protein Name | Caspase-5Casp-5Ice(Rel-IiiProtease Ich-3Protease Ty Cleaved Into - Caspase-5 Subunit P20 - Caspase-5 Subunit P10 |
| Database Links | Reactome: R-HSA-5620971 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Caspase-5 antibodyAnti-Casp-5 antibodyAnti-Ice(Rel-Iii antibodyAnti-Protease Ich-3 antibodyAnti-Protease Ty Cleaved Into - Caspase-5 Subunit P20 - Caspase-5 Subunit P10 antibodyAnti-CASP5 antibodyAnti-ICH3 antibody |
Information sourced from Uniprot.org